Crystie Wong scored 12 points and Ashlee De Santos added 11 as the Spartans beat Ka Makani.
Maryknoll went on a 9-0 run to end the third period and take a 35-26 advantage.
Hawaii Prep got within 41-38 with 2:19 left, before Maryknoll pulled away.
Chancis Fernandez had 18 points and 10 rebounds for Ka Makani.
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